Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis

Leif E. Peterson; Matthew A. Coleman

doi:10.1007/11676935_33

Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis

Leif E. Peterson, Matthew A. Coleman

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

10 Scopus citations

Abstract

A combination of gene ranking, dimensional reduction, and recursive feature elimination (RFE) using a BP-MLP artificial neural network (ANN) was used to select genes for DNA microarray classification. Use of k-means cluster analysis for dimensional reduction and maximum sensitivity for RFE resulted in 64-gene models with fewer invariant and correlated features when compared with PCA and mimimum error. In conclusion, k-means cluster analysis and sensitivity may be better suited for classifying diseases for which gene expression is more strongly influenced by pathway heterogeneity.

Original language	English (US)
Title of host publication	Fuzzy Logic and Applications - 6th International Workshop, WILF 2005, Revised Selected Papers
Publisher	Springer-Verlag
Pages	267-276
Number of pages	10
ISBN (Print)	3540325298, 9783540325291
DOIs	https://doi.org/10.1007/11676935_33
State	Published - 2006
Event	6th International Workshop - Fuzzy Logic and Applications - Crema, Italy Duration: Sep 15 2005 → Sep 17 2005

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	3849 LNAI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	6th International Workshop - Fuzzy Logic and Applications
Country/Territory	Italy
City	Crema
Period	9/15/05 → 9/17/05

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

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10.1007/11676935_33

Cite this

Peterson, L. E., & Coleman, M. A. (2006). Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis. In Fuzzy Logic and Applications - 6th International Workshop, WILF 2005, Revised Selected Papers (pp. 267-276). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3849 LNAI). Springer-Verlag. https://doi.org/10.1007/11676935_33

Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis. / Peterson, Leif E.; Coleman, Matthew A.

Fuzzy Logic and Applications - 6th International Workshop, WILF 2005, Revised Selected Papers. Springer-Verlag, 2006. p. 267-276 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3849 LNAI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Peterson, LE & Coleman, MA 2006, Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis. in Fuzzy Logic and Applications - 6th International Workshop, WILF 2005, Revised Selected Papers. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 3849 LNAI, Springer-Verlag, pp. 267-276, 6th International Workshop - Fuzzy Logic and Applications, Crema, Italy, 9/15/05. https://doi.org/10.1007/11676935_33

Peterson LE, Coleman MA. Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis. In Fuzzy Logic and Applications - 6th International Workshop, WILF 2005, Revised Selected Papers. Springer-Verlag. 2006. p. 267-276. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/11676935_33

Peterson, Leif E. ; Coleman, Matthew A. / Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis. Fuzzy Logic and Applications - 6th International Workshop, WILF 2005, Revised Selected Papers. Springer-Verlag, 2006. pp. 267-276 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis

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