Comparison of coronary plaque subtypes in male and female patients using 320-row MDCTA

Faisal Khosa, Atif N. Khan, Khurram Nasir, Arash Bedayat, Zehra Malik, Ali F. Jon, Ahmad R. Cheema, Melvin E. Clouse, Francine K. Welty

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: Determine plaque subtype and volume difference in male and female patients with obstructive and non-obstructive CAD using 320-row MDCTA. Materials and methods: 128 patients with suspected CAD underwent MDCTA. All studies were divided into two groups based on disease severity. 0-70% stenosis (non-obstructive CAD) & >70% (obstructive). All were compared for plaque quantity and subtypes by gender. Main arteries, RCA, LM, LAD and LCX were analyzed using Vitrea 5.2 software to quantify fatty, fibrous and calcified plaque. Thresholds for coronary plaque quantification (volume in mm3) were preset at 35 ± 12 HU for fatty, 90 ± 24 HU for fibrous and >130 HU for calcified/mixed plaque and analyzed using STATA software. Results: Total plaque burden in 118 patients [65M: 53F] was significantly higher in all arteries in males compared to females with non-obstructive disease. Total plaque volume for males vs. females was: RCA: 10.10 ± 5.02 mm3 vs. 6.89 ± 2.75 mm3, respectively, p = 0.001; LAD: 7.21 ± 3.38 mm3 vs. 5.89 ± 1.93 mm3, respectively, p = 0.04; LCX: 9.13 ± 3.27 mm3 vs. 7.16 ± 1.73 mm3, respectively, p = 0.002; LM 15.13 ± 4.51 mm3 vs. 11.85 ± 4.03 mm3, respectively, p = 0.001. In sub-analyses, males had significantly more fibrous and fatty plaque in LM, LAD & LCX than females. However in the RCA, only fibrous plaque was significantly greater in males. Calcified plaque volume was not significantly different in both genders. Only 8% of patients had obstructive CAD (>70% stenosis); there was no significant difference in plaque volume or subtypes. Conclusion: In patients with non-obstructive CAD, males were found to have significantly higher total coronary plaque volume with predominance of fibrous and fatty subtypes compared to females of the same age and BMI. There was no significant difference in plaque subtype or volume in patients with obstructive disease.

Original languageEnglish (US)
Pages (from-to)428-432
Number of pages5
JournalAtherosclerosis
Volume226
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • 320-row MDCTA
  • Coronary artery disease
  • Coronary plaque subtypes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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