Comparison of adrenal cortical tumors in children and adults

Philip T. Cagle, Aubrey J. Hough, T. Pysher Jeffrey, David L. Page, Ed H. Johnson, Rebecca T. Kirkland, John H. Holcombe, Edith P. Hawkins

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Morphologic features (abnormal mitoses, necrosis, vascular and capsular invasion, broad fibrous bands, cellular pleomorphism, size) previously suggested to be predictors of malignant behavior in adrenal cortical tumors were assessed individually in 23 (17 benign, 6 malignant) pediatric and 42 (29 benign, 13 malignant) adults tumors. Of these features, size was only predictor of malignancy in pediatric tumors. All pediatric tumors weighing more than 500 g were malignant and all but one weighing less than 500 g were benign. The remaining features were present in both benign and malignant pediatric tumors, and pediatric benign tumors were significantly more likely to have mitoses (P < 0.01), necrosis (P < 0.001), broad fibrous bands (P < 0.005), and moderate to severe pleomorphism (P < 0.01) than were adult benign tumors. The authors conclude that pediatric tumors are more likely to be benign than previously thought, and that size is the only morphologic predictor of their biologic behavior.

Original languageEnglish (US)
Pages (from-to)2235-2237
Number of pages3
Issue number11
StatePublished - Jun 1 1986

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Comparison of adrenal cortical tumors in children and adults'. Together they form a unique fingerprint.

Cite this