Comparative kinetic study of the binding between 2,3,7,8‐tetrachlorodibenzo‐ρ‐dioxin and related ligands with the hepatic Ah receptors from several rodent species

Jamie S. Nakai, Martha J. Winhall, Nigel J. Bunce, Rhonda Rosengren, Stephen Safe

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Kinetic analysis of the time course of association of [3H]‐2,3,7,8‐tetrachlorodibenzo‐ρ‐dioxin with hepatic cytosoi from five rodent species gave additional evidence for differences in the properties of the Ah receptor ligand binding subunit between species. A parallel study of the association of six tritiated polychlorinated dibenzopρ‐dioxins and dibenzofurans with hepatic Ah receptor from Wistar rat and C57BL/6 mouse showed that their rank order for kinetic affinity did not correlate with the rank ordering of their toxic potency‐ and may vary according to the source of the Ah receptor.

Original languageEnglish (US)
Pages (from-to)199-209
Number of pages11
JournalJournal of Biochemical Toxicology
Volume9
Issue number4
DOIs
StatePublished - Aug 1994
Externally publishedYes

Keywords

  • Ah Receptor
  • Kinetics
  • PCDD
  • PCDF
  • TCDD

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Comparative kinetic study of the binding between 2,3,7,8‐tetrachlorodibenzo‐ρ‐dioxin and related ligands with the hepatic Ah receptors from several rodent species'. Together they form a unique fingerprint.

Cite this