TY - JOUR
T1 - Comparative in vitro and in vivo efficacy of roxithromycin and erythromycin against a strain of methicillin-susceptible Staphylococcus epidermidis
AU - Danias, Peter G.
AU - Chalevelakis, G.
AU - Mylonakis, E. E.
AU - Argyropoulou, A.
AU - Paniara, O.
AU - Saroglou, G.
AU - Raptis, S. A.
N1 - Funding Information:
This work was supported by an educational research grant from the University of Athens School of Medicine and the Second Department of Medicine—Propaedeutic, Evangelismos Hospital, Athens, Greece.
PY - 1998/9
Y1 - 1998/9
N2 - The in vitro and in vivo efficacy of roxithromycin was compared with that of erythromycin, against a methicillin-susceptible strain of Staphylococcus epidermidis. We performed standard in vitro testing (MIC, MBC, and time-kill kinetics) for roxithromycin, erythromycin, and rifampin. Both macrolides were bacteriostatic in vitro. There was no significant difference in microbial survival between erythromycin and roxithromycin groups in the time-kill kinetics (p = 0.3). For the in vivo experiments, using the rabbit experimental endocarditis model, roxithromycin was found to be inferior to erythromycin in decreasing the microbial burden of the endocardial vegetations (p <0.05). Rifampin was highly effective, both in vitro and in vivo. In conclusion, the efficacy of roxithromycin was poor and inferior to erythromycin against a strain of methicillin-susceptible S. epidermidis. Copyright (C) 1998 Elsevier Science Inc.
AB - The in vitro and in vivo efficacy of roxithromycin was compared with that of erythromycin, against a methicillin-susceptible strain of Staphylococcus epidermidis. We performed standard in vitro testing (MIC, MBC, and time-kill kinetics) for roxithromycin, erythromycin, and rifampin. Both macrolides were bacteriostatic in vitro. There was no significant difference in microbial survival between erythromycin and roxithromycin groups in the time-kill kinetics (p = 0.3). For the in vivo experiments, using the rabbit experimental endocarditis model, roxithromycin was found to be inferior to erythromycin in decreasing the microbial burden of the endocardial vegetations (p <0.05). Rifampin was highly effective, both in vitro and in vivo. In conclusion, the efficacy of roxithromycin was poor and inferior to erythromycin against a strain of methicillin-susceptible S. epidermidis. Copyright (C) 1998 Elsevier Science Inc.
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U2 - 10.1016/S0732-8893(98)00059-5
DO - 10.1016/S0732-8893(98)00059-5
M3 - Article
C2 - 9791758
AN - SCOPUS:0032426630
VL - 32
SP - 51
EP - 54
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
SN - 0732-8893
IS - 1
ER -