Comparative effects of torasemide and furosemide in rats with heart failure

Punniyakoti T. Veeraveedu, Kenichi Watanabe, Meilei Ma, Rajarajan A. Thandavarayan, Suresh S. Palaniyandi, Ken'ichi Yamaguchi, Kenji Suzuki, Makoto Kodama, Yoshifusa Aizawa

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

It has been reported that torasemide but not furosemide, may block the renin-angiotensin-aldosterone system and therefore it might attenuate myocardial remodeling accompanied by left ventricular (LV) dysfunction. We therefore compared the therapeutic effects of torasemide, a long-acting loop diuretic, and furosemide, a short-acting one, on the progression of LV remodeling in a rat model of chronic heart failure (CHF) after experimental autoimmune myocarditis (EAM). CHF was elicited in Lewis rats by immunization with porcine cardiac myosin. Twenty-eight days after immunization, rats were treated for 28 days with torasemide, furosemide, or vehicle. We investigated the effects on metabolic and neurohumoral parameters, cardiac fibrosis and remodeling in EAM rats. Diuresis was increased dose dependently by both torasemide and furosemide, showed an equipotent natriuretic effect. The urinary potassium excretion was significantly increased with furosemide in comparison to torasemide. Myocardial functional parameters were significantly improved by torasemide. Conversely, these parameters did not change in rats receiving furosemide. Torasemide suppressed LV fibrosis, myocardial protein levels of transforming growth factor-beta1, collagen III, and aldosterone synthase and improved survival rate to the control level, but furosemide did not. Moreover, both pharmacological interventions significantly elevated plasma angiotensin II and decreased atrial natriuretic peptide in a dose-dependent manner. Our results demonstrate that compared with furosemide, torasemide treatment significantly improved survival rate, LV function and ameliorated the progression of cardiac remodeling in rats with CHF after EAM.

Original languageEnglish (US)
Pages (from-to)649-659
Number of pages11
JournalBiochemical pharmacology
Volume75
Issue number3
DOIs
StatePublished - Feb 1 2008

Keywords

  • Aldosterone
  • Experimental autoimmune myocarditis
  • Fibrosis
  • Furosemide
  • Remodeling
  • Torasemide

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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