Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on MCF-7, RL95-2, and LNCaP cells: Role of target steroid hormones in cellular responsiveness to CYP1A1 induction

Keyphrases

• 2,3,7,8-tetrachlorodibenzo-p-dioxin 100%
• LNCaP Cells 100%
• Steroid Hormones 100%
• MCF-7 100%
• CYP1A Induction 100%
• RL95-2 100%
• Ethoxyresorufin-O-deethylase 25%
• Gene Activity 16%
• Reporter Gene 16%
• Aryl Hydrocarbon Receptor 16%
• Cytochrome P450 1A1 (CYP1A1) 8%
• Expression Level 8%
• Breast 8%
• Steady State 8%
• Estradiol Receptor 8%
• Cancer Cell Lines 8%
• Activity-dependent 8%
• Prostate 8%
• Testosterone 8%
• LNCaP 8%
• Negatively Regulate 8%
• DNA Methylation (DNAm) 8%
• Co-expression 8%
• PAI-2 8%
• Core Sequence 8%
• CYP1B1 8%
• Reporter Plasmid 8%
• DNA Methyltransferase Inhibitor 8%
• Experimental Model Systems 8%
• CYP1A1 Gene 8%
• CpG Dinucleotide 8%
• Inducible Gene Expression 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Steroid Hormone 100%
• 2,3,7,8-Tetrachlorodibenzodioxin 100%
• Cytochrome P450 1A1 100%
• Ethoxyresorufin 25%
• Malignant Neoplasm 8%
• Estradiol Receptor 8%
• Aromatic Hydrocarbon Receptor 8%
• CYP1B1 8%
• DNA Methyltransferase Inhibitor 8%
• Hypoxia Inducible Factor 1beta 8%
• Dinucleotide 8%