Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design

Craig Pratt, J. B. Young, M. J. Francis, A. A. Taylor, H. J. Norton, L. English, D. E. Mann, H. Kopelen, Miguel A. Quiñones, R. Roberts

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

This placebo-controlled, double-blind, longitudinal crossover study compares the efficacy of disopyramide and ethmozine, a new investigational drug, in suppressing frequent (40 or more per hour) ventricular premature depolarizations (VPDs) in 27 patients completing a 37-day protocol. Although both drugs significantly reduced VPDs relative to placebo, ethmozine was a superior antiarrhythmic drug in achieving near-total abolition of VPDs (30% of patients), which was never observed during disopyramide dosing (p < .05). At the 80% VPD reduction level, ethmozine was effective in 56% of all patients with an effectiveness in only 22% of patients during disopyramide therapy (p < .05). The mean peak plasma level of ethmozine was 0.66 ± 0.8 μg/ml, which significantly fell to a trough level of 0.1 ± 0.08 μg/ml (p < .001). Mean peak and trough plasma levels of disopyramide exhibited less fluctuation (2.6 ± 0.9 μg/ml vs 2.2 ± 0.9 μg/ml). Ethmozine had no effect on the QT(c) interval, whereas disopyramide prolonged it significantly. Importantly, while disopyramide produced serious side effects in 30% of patients, ethmozine was well tolerated with no statistically significant side effects compared with placebo.

Original languageEnglish (US)
Pages (from-to)288-297
Number of pages10
JournalCirculation
Volume69
Issue number2
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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