Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture

T. W. Sawyer, A. D. Vatcher, S. Safe

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The activities of several commercial PCB mixtures as inducers of microsomal aryl hydroarbon hydroxylase (AHH) and ethoxyresorufin 0-deethylase (EROD) in male Wistar rats and rat hepatoma cells were dependent on the chlorine content (and congener distribution) of the mixtures. The was a correlation between the in vivo and in vitro induction potencies of these mixtures; the most active mixtures, Aroclors 1242, 1248 and 1254 contained 42-54% by weight of Cl whereas formulations with higher or lower (Aroclors 1221 and 1268 respectively) chlorine content exhibited lower activities. This corresponds with studies reported for PCB isomers and congeners in which the most active compounds are tetra-hexachlorobiphenyls.

Original languageEnglish (US)
Pages (from-to)695-701
Number of pages7
JournalChemosphere
Volume13
Issue number7
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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