Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture

T. W. Sawyer; A. D. Vatcher; S. Safe

doi:10.1016/0045-6535(84)90173-5

Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture

T. W. Sawyer, A. D. Vatcher, S. Safe

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Abstract

The activities of several commercial PCB mixtures as inducers of microsomal aryl hydroarbon hydroxylase (AHH) and ethoxyresorufin 0-deethylase (EROD) in male Wistar rats and rat hepatoma cells were dependent on the chlorine content (and congener distribution) of the mixtures. The was a correlation between the in vivo and in vitro induction potencies of these mixtures; the most active mixtures, Aroclors 1242, 1248 and 1254 contained 42-54% by weight of Cl whereas formulations with higher or lower (Aroclors 1221 and 1268 respectively) chlorine content exhibited lower activities. This corresponds with studies reported for PCB isomers and congeners in which the most active compounds are tetra-hexachlorobiphenyls.

Original language	English (US)
Pages (from-to)	695-701
Number of pages	7
Journal	Chemosphere
Volume	13
Issue number	7
DOIs	https://doi.org/10.1016/0045-6535(84)90173-5
State	Published - 1984

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Chemistry(all)
Pollution
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(84)90173-5

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title = "Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture",

abstract = "The activities of several commercial PCB mixtures as inducers of microsomal aryl hydroarbon hydroxylase (AHH) and ethoxyresorufin 0-deethylase (EROD) in male Wistar rats and rat hepatoma cells were dependent on the chlorine content (and congener distribution) of the mixtures. The was a correlation between the in vivo and in vitro induction potencies of these mixtures; the most active mixtures, Aroclors 1242, 1248 and 1254 contained 42-54% by weight of Cl whereas formulations with higher or lower (Aroclors 1221 and 1268 respectively) chlorine content exhibited lower activities. This corresponds with studies reported for PCB isomers and congeners in which the most active compounds are tetra-hexachlorobiphenyls.",

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T1 - Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture

AU - Sawyer, T. W.

AU - Vatcher, A. D.

AU - Safe, S.

PY - 1984

Y1 - 1984

N2 - The activities of several commercial PCB mixtures as inducers of microsomal aryl hydroarbon hydroxylase (AHH) and ethoxyresorufin 0-deethylase (EROD) in male Wistar rats and rat hepatoma cells were dependent on the chlorine content (and congener distribution) of the mixtures. The was a correlation between the in vivo and in vitro induction potencies of these mixtures; the most active mixtures, Aroclors 1242, 1248 and 1254 contained 42-54% by weight of Cl whereas formulations with higher or lower (Aroclors 1221 and 1268 respectively) chlorine content exhibited lower activities. This corresponds with studies reported for PCB isomers and congeners in which the most active compounds are tetra-hexachlorobiphenyls.

AB - The activities of several commercial PCB mixtures as inducers of microsomal aryl hydroarbon hydroxylase (AHH) and ethoxyresorufin 0-deethylase (EROD) in male Wistar rats and rat hepatoma cells were dependent on the chlorine content (and congener distribution) of the mixtures. The was a correlation between the in vivo and in vitro induction potencies of these mixtures; the most active mixtures, Aroclors 1242, 1248 and 1254 contained 42-54% by weight of Cl whereas formulations with higher or lower (Aroclors 1221 and 1268 respectively) chlorine content exhibited lower activities. This corresponds with studies reported for PCB isomers and congeners in which the most active compounds are tetra-hexachlorobiphenyls.

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Comparative aryl hydrocarbon hydroxylase induction activities of commercial PCBs in Wistar rats and rat hepatoma H-4-II E cells in culture

Abstract

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