Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

Soraya L. Moghazeh; Xi Pan; Taraq Arain; C. Kendall Stover; James M. Musser; Barry N. Kreiswirth

doi:10.1128/aac.40.11.2655

Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

Soraya L. Moghazeh, Xi Pan, Taraq Arain, C. Kendall Stover, James M. Musser, Barry N. Kreiswirth

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

A collection of 24 rifampin-resistant clinical isolates of Mycobacterium tuberculosis with characterized RNA polymerase β-subunit (rpoB) gene mutations was tested against the antimycobacterial agents rifampin, rifapentine, and KRM-1648 to correlate levels of resistance with specific rpoB genotypes. The results indicate that KRM-1648 is more active in vitro than rifampin and rifapentine, and its ability to overcome rifampin resistance in strains with four different genetic alterations may prove to be useful in understanding structure-function relationships.

Original language	English (US)
Pages (from-to)	2655-2657
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	40
Issue number	11
DOIs	https://doi.org/10.1128/aac.40.11.2655
State	Published - Nov 1996

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Moghazeh, S. L., Pan, X., Arain, T., Stover, C. K., Musser, J. M., & Kreiswirth, B. N. (1996). Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. Antimicrobial Agents and Chemotherapy, 40(11), 2655-2657. https://doi.org/10.1128/aac.40.11.2655

Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. / Moghazeh, Soraya L.; Pan, Xi; Arain, Taraq et al.

In: Antimicrobial Agents and Chemotherapy, Vol. 40, No. 11, 11.1996, p. 2655-2657.

Research output: Contribution to journal › Article › peer-review

Moghazeh, SL, Pan, X, Arain, T, Stover, CK, Musser, JM & Kreiswirth, BN 1996, 'Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations', Antimicrobial Agents and Chemotherapy, vol. 40, no. 11, pp. 2655-2657. https://doi.org/10.1128/aac.40.11.2655

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Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

Abstract

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