TY - JOUR
T1 - Comparative Analysis of Porcine and Human Thoracic Aortic Stiffness
AU - de Beaufort, Hector W.L.
AU - Ferrara, Anna
AU - Conti, Michele
AU - Moll, Frans L.
AU - van Herwaarden, Joost A.
AU - Figueroa, C. Alberto
AU - Bismuth, Jean
AU - Auricchio, Ferdinando
AU - Trimarchi, Santi
N1 - Publisher Copyright:
© 2017 European Society for Vascular Surgery
PY - 2018/4
Y1 - 2018/4
N2 - Objectives: To compare porcine and human thoracic aortic stiffness using the available literature. Methods: The available literature was searched for studies reporting data on porcine or human thoracic aortic mechanical behaviour. A four fibre constitutive model was used to transform the data from included studies. Thus, equi-biaxial stress stretch curves were generated to calculate circumferential and longitudinal aortic stiffness. Analysis was performed separately for the ascending and descending thoracic aorta. Data on human aortic stiffness were divided by age <60 or ≥60 years. Porcine and human aortic stiffness were compared. Results: Eleven studies were included, six reported on young porcine aortas, four on human aortas of various ages, and one reported on both. In the ascending aorta, circumferential and longitudinal stiffness were 0.42±0.08 MPa and 0.37±0.06 MPa for porcine aortas (4–9 months) versus 0.55±0.15 MPa and 0.45±0.08 MPa for humans <60 years, and 1.02±0.59 MPa and 1.03±0.54 MPa for humans ≥60 years. In the descending aorta, circumferential and longitudinal stiffness were 0.46±0.03 MPa and 0.44±0.01 MPa for porcine aortas (4–10 months) versus 1.04±0.70 MPa and 1.24±0.76 MPa for humans <60 years, and 3.15±3.31 MPa and 1.17±0.31 MPa for humans ≥60 years. Conclusions: The stiffness of young porcine aortic tissue shows good correspondence with human tissue aged <60 years, especially in the ascending aorta. Young porcine aortic tissue is less stiff than human aortic tissue aged ≥60 years.
AB - Objectives: To compare porcine and human thoracic aortic stiffness using the available literature. Methods: The available literature was searched for studies reporting data on porcine or human thoracic aortic mechanical behaviour. A four fibre constitutive model was used to transform the data from included studies. Thus, equi-biaxial stress stretch curves were generated to calculate circumferential and longitudinal aortic stiffness. Analysis was performed separately for the ascending and descending thoracic aorta. Data on human aortic stiffness were divided by age <60 or ≥60 years. Porcine and human aortic stiffness were compared. Results: Eleven studies were included, six reported on young porcine aortas, four on human aortas of various ages, and one reported on both. In the ascending aorta, circumferential and longitudinal stiffness were 0.42±0.08 MPa and 0.37±0.06 MPa for porcine aortas (4–9 months) versus 0.55±0.15 MPa and 0.45±0.08 MPa for humans <60 years, and 1.02±0.59 MPa and 1.03±0.54 MPa for humans ≥60 years. In the descending aorta, circumferential and longitudinal stiffness were 0.46±0.03 MPa and 0.44±0.01 MPa for porcine aortas (4–10 months) versus 1.04±0.70 MPa and 1.24±0.76 MPa for humans <60 years, and 3.15±3.31 MPa and 1.17±0.31 MPa for humans ≥60 years. Conclusions: The stiffness of young porcine aortic tissue shows good correspondence with human tissue aged <60 years, especially in the ascending aorta. Young porcine aortic tissue is less stiff than human aortic tissue aged ≥60 years.
KW - Aorta
KW - Elastic modulus
KW - Material properties
KW - Porcine model
KW - Stiffness
KW - Translational research
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U2 - 10.1016/j.ejvs.2017.12.014
DO - 10.1016/j.ejvs.2017.12.014
M3 - Article
C2 - 29402669
AN - SCOPUS:85041293651
SN - 1078-5884
VL - 55
SP - 560
EP - 566
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
IS - 4
ER -