TY - JOUR
T1 - Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains
AU - Mucenski, M. L.
AU - Gilbert, D. J.
AU - Taylor, B. A.
AU - Jenkins, Nancy A.
AU - Copeland, Neal G.
PY - 1987/12/1
Y1 - 1987/12/1
N2 - Lymphomas from 21 AKXD recombinant inbred mouse strains were analyzed for retrovirally induced rearrangements in seven known or putative proto-concogene loci. Among the rearrangements detected in the 258 lymphomas screened, most rearrangements appeared to be caused by viral integration. Rearrangements were detected in the Myc, Pvt-1, Pim-1, Mlvi-1, Mlvi-2, and Fis-1 loci, but not in the Myb locus. Seven lymphomas contained rearrangements in two loci. Nearly 90% of the rearrangements were observed in T cell lymphomas; few were detected in B cell or myeloid tumors. Rearrangements in Pvt-1, Fis-1, Mlvi-1, and Mlvi-2 were identified only in T cell lymphomas. Alterations in the Myc and Pim-1 loci, although occurring predominantly in T cell lymphomas, were occasionally detected in other types of lymphoma. These data suggest that the repertoire of cellular proto-oncogenes activated by integration of virus into lymphomas may be different for each hematopoietic cell lineage. The AKXD lymphomas represent a useful resource for identifying these sites.
AB - Lymphomas from 21 AKXD recombinant inbred mouse strains were analyzed for retrovirally induced rearrangements in seven known or putative proto-concogene loci. Among the rearrangements detected in the 258 lymphomas screened, most rearrangements appeared to be caused by viral integration. Rearrangements were detected in the Myc, Pvt-1, Pim-1, Mlvi-1, Mlvi-2, and Fis-1 loci, but not in the Myb locus. Seven lymphomas contained rearrangements in two loci. Nearly 90% of the rearrangements were observed in T cell lymphomas; few were detected in B cell or myeloid tumors. Rearrangements in Pvt-1, Fis-1, Mlvi-1, and Mlvi-2 were identified only in T cell lymphomas. Alterations in the Myc and Pim-1 loci, although occurring predominantly in T cell lymphomas, were occasionally detected in other types of lymphoma. These data suggest that the repertoire of cellular proto-oncogenes activated by integration of virus into lymphomas may be different for each hematopoietic cell lineage. The AKXD lymphomas represent a useful resource for identifying these sites.
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M3 - Article
C2 - 3505665
AN - SCOPUS:0023638447
SN - 0890-6467
VL - 2
SP - 33
EP - 48
JO - Oncogene Research
JF - Oncogene Research
IS - 1
ER -