Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains

M. L. Mucenski, D. J. Gilbert, B. A. Taylor, Nancy A. Jenkins, Neal G. Copeland

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42 Scopus citations


Lymphomas from 21 AKXD recombinant inbred mouse strains were analyzed for retrovirally induced rearrangements in seven known or putative proto-concogene loci. Among the rearrangements detected in the 258 lymphomas screened, most rearrangements appeared to be caused by viral integration. Rearrangements were detected in the Myc, Pvt-1, Pim-1, Mlvi-1, Mlvi-2, and Fis-1 loci, but not in the Myb locus. Seven lymphomas contained rearrangements in two loci. Nearly 90% of the rearrangements were observed in T cell lymphomas; few were detected in B cell or myeloid tumors. Rearrangements in Pvt-1, Fis-1, Mlvi-1, and Mlvi-2 were identified only in T cell lymphomas. Alterations in the Myc and Pim-1 loci, although occurring predominantly in T cell lymphomas, were occasionally detected in other types of lymphoma. These data suggest that the repertoire of cellular proto-oncogenes activated by integration of virus into lymphomas may be different for each hematopoietic cell lineage. The AKXD lymphomas represent a useful resource for identifying these sites.

Original languageEnglish (US)
Pages (from-to)33-48
Number of pages16
JournalOncogene Research
Issue number1
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Cancer Research


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