Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains

M. L. Mucenski, D. J. Gilbert, B. A. Taylor, Nancy A. Jenkins, Neal G. Copeland

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Lymphomas from 21 AKXD recombinant inbred mouse strains were analyzed for retrovirally induced rearrangements in seven known or putative proto-concogene loci. Among the rearrangements detected in the 258 lymphomas screened, most rearrangements appeared to be caused by viral integration. Rearrangements were detected in the Myc, Pvt-1, Pim-1, Mlvi-1, Mlvi-2, and Fis-1 loci, but not in the Myb locus. Seven lymphomas contained rearrangements in two loci. Nearly 90% of the rearrangements were observed in T cell lymphomas; few were detected in B cell or myeloid tumors. Rearrangements in Pvt-1, Fis-1, Mlvi-1, and Mlvi-2 were identified only in T cell lymphomas. Alterations in the Myc and Pim-1 loci, although occurring predominantly in T cell lymphomas, were occasionally detected in other types of lymphoma. These data suggest that the repertoire of cellular proto-oncogenes activated by integration of virus into lymphomas may be different for each hematopoietic cell lineage. The AKXD lymphomas represent a useful resource for identifying these sites.

Original languageEnglish (US)
Pages (from-to)33-48
Number of pages16
JournalOncogene Research
Volume2
Issue number1
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Cancer Research

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