TY - JOUR
T1 - Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans
AU - Austin, Celest M.
AU - Ma, Xin
AU - Graviss, Edward A.
N1 - Funding Information:
Received 6 September 2007; accepted 28 December 2007; electronically published 17 April 2008. Potential conflicts of interest: none reported. Financial support: National Institute of Allergy and Infectious Diseases, National Institutes of Health (contracts N01-AO-02738 and AI 41168); Katharine H. K. Hsu Foundation; Vivian L. Smith Foundation. Reprints or correspondence: Dr. Xin Ma, Dept. of Pathology (209E), Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 ([email protected]).
PY - 2008/6/15
Y1 - 2008/6/15
N2 - Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.
AB - Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.
UR - https://www.scopus.com/pages/publications/46349104997
UR - https://www.scopus.com/inward/citedby.url?scp=46349104997&partnerID=8YFLogxK
U2 - 10.1086/588384
DO - 10.1086/588384
M3 - Article
C2 - 18419343
AN - SCOPUS:46349104997
SN - 0022-1899
VL - 197
SP - 1713
EP - 1716
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -