Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans

Celest M. Austin, Xin Ma, Edward A. Graviss

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.

Original languageEnglish (US)
Pages (from-to)1713-1716
Number of pages4
JournalJournal of Infectious Diseases
Volume197
Issue number12
DOIs
StatePublished - Jun 15 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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