Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans

Celest M. Austin; Xin Ma; Edward A. Graviss

doi:10.1086/588384

Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans

Celest M. Austin, Xin Ma, Edward A. Graviss

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.

Original language	English (US)
Pages (from-to)	1713-1716
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	197
Issue number	12
DOIs	https://doi.org/10.1086/588384
State	Published - Jun 15 2008

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/588384

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title = "Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans",

abstract = "Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.",

author = "Austin, {Celest M.} and Xin Ma and Graviss, {Edward A.}",

note = "Funding Information: Received 6 September 2007; accepted 28 December 2007; electronically published 17 April 2008. Potential conflicts of interest: none reported. Financial support: National Institute of Allergy and Infectious Diseases, National Institutes of Health (contracts N01-AO-02738 and AI 41168); Katharine H. K. Hsu Foundation; Vivian L. Smith Foundation. Reprints or correspondence: Dr. Xin Ma, Dept. of Pathology (209E), Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 (xma@bcm.edu).",

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T1 - Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans

AU - Austin, Celest M.

AU - Ma, Xin

AU - Graviss, Edward A.

N1 - Funding Information: Received 6 September 2007; accepted 28 December 2007; electronically published 17 April 2008. Potential conflicts of interest: none reported. Financial support: National Institute of Allergy and Infectious Diseases, National Institutes of Health (contracts N01-AO-02738 and AI 41168); Katharine H. K. Hsu Foundation; Vivian L. Smith Foundation. Reprints or correspondence: Dr. Xin Ma, Dept. of Pathology (209E), Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 (xma@bcm.edu).

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Y1 - 2008/6/15

N2 - Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.

AB - Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms - Pro268Ser, Arg702Trp, and Ala725Gly - demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.

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Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans

Abstract

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