Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging

and the Curing Coma Campaign and its Contributing Members

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Over the past 5 decades, advances in neuroimaging have yielded insights into the pathophysiologic mechanisms that cause disorders of consciousness (DoC) in patients with severe brain injuries. Structural, functional, metabolic, and perfusion imaging studies have revealed specific neuroanatomic regions, such as the brainstem tegmentum, thalamus, posterior cingulate cortex, medial prefrontal cortex, and occipital cortex, where lesions correlate with the current or future state of consciousness. Advanced imaging modalities, such as diffusion tensor imaging, resting-state functional magnetic resonance imaging (fMRI), and task-based fMRI, have been used to improve the accuracy of diagnosis and long-term prognosis, culminating in the endorsement of fMRI for the clinical evaluation of patients with DoC in the 2018 US (task-based fMRI) and 2020 European (task-based and resting-state fMRI) guidelines. As diverse neuroimaging techniques are increasingly used for patients with DoC in research and clinical settings, the need for a standardized approach to reporting results is clear. The success of future multicenter collaborations and international trials fundamentally depends on the implementation of a shared nomenclature and infrastructure. Methods: To address this need, the Neurocritical Care Society’s Curing Coma Campaign convened an international panel of DoC neuroimaging experts to propose common data elements (CDEs) for data collection and reporting in this field. Results: We report the recommendations of this CDE development panel and disseminate CDEs to be used in neuroimaging studies of patients with DoC. Conclusions: These CDEs will support progress in the field of DoC neuroimaging and facilitate international collaboration.

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalNeurocritical Care
Issue number3
StatePublished - Dec 2023


  • Coma
  • Common data elements
  • Consciousness
  • Neuroimaging

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology


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