Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice

Herbert C. Morse, Chen Feng Qi, Sisir K. Chattopadhyay, Mitsuo Hori, Lekidelu Taddesse-Heath, Keiko Ozato, Janet W. Hartley, Benjamin A. Taylor, Jerrold M. Ward, Nancy A. Jenkins, Neal G. Copeland, Torgny N. Fredrickson

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V+ and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.

Original languageEnglish (US)
Pages (from-to)719-733
Number of pages15
JournalLeukemia Research
Volume25
Issue number8
DOIs
StatePublished - 2001

Keywords

  • Diffuse large cell lymphoma
  • Mouse B-cell lymphoma
  • Oncogene
  • Proviral insertional mutagenesis
  • Splenic marginal zone lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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