Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice

Herbert C. Morse; Chen Feng Qi; Sisir K. Chattopadhyay; Mitsuo Hori; Lekidelu Taddesse-Heath; Keiko Ozato; Janet W. Hartley; Benjamin A. Taylor; Jerrold M. Ward; Nancy A. Jenkins; Neal G. Copeland; Torgny N. Fredrickson

doi:10.1016/S0145-2126(01)00022-4

Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice

Herbert C. Morse, Chen Feng Qi, Sisir K. Chattopadhyay, Mitsuo Hori, Lekidelu Taddesse-Heath, Keiko Ozato, Janet W. Hartley, Benjamin A. Taylor, Jerrold M. Ward, Nancy A. Jenkins, Neal G. Copeland, Torgny N. Fredrickson

Research output: Contribution to journal › Article

26 Scopus citations

Abstract

Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V⁺ and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.

Original language	English (US)
Pages (from-to)	719-733
Number of pages	15
Journal	Leukemia Research
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/S0145-2126(01)00022-4
State	Published - 2001

Keywords

Diffuse large cell lymphoma
Mouse B-cell lymphoma
Oncogene
Proviral insertional mutagenesis
Splenic marginal zone lymphoma

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/S0145-2126(01)00022-4

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Morse, H. C., Qi, C. F., Chattopadhyay, S. K., Hori, M., Taddesse-Heath, L., Ozato, K., Hartley, J. W., Taylor, B. A., Ward, J. M., Jenkins, N. A., Copeland, N. G., & Fredrickson, T. N. (2001). Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice. Leukemia Research, 25(8), 719-733. https://doi.org/10.1016/S0145-2126(01)00022-4

Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice. / Morse, Herbert C.; Qi, Chen Feng; Chattopadhyay, Sisir K.; Hori, Mitsuo; Taddesse-Heath, Lekidelu; Ozato, Keiko; Hartley, Janet W.; Taylor, Benjamin A.; Ward, Jerrold M.; Jenkins, Nancy A.; Copeland, Neal G.; Fredrickson, Torgny N.

In: Leukemia Research, Vol. 25, No. 8, 2001, p. 719-733.

Research output: Contribution to journal › Article

Morse, HC, Qi, CF, Chattopadhyay, SK, Hori, M, Taddesse-Heath, L, Ozato, K, Hartley, JW, Taylor, BA, Ward, JM, Jenkins, NA , Copeland, NG & Fredrickson, TN 2001, 'Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice', Leukemia Research, vol. 25, no. 8, pp. 719-733. https://doi.org/10.1016/S0145-2126(01)00022-4

Morse, Herbert C. ; Qi, Chen Feng ; Chattopadhyay, Sisir K. ; Hori, Mitsuo ; Taddesse-Heath, Lekidelu ; Ozato, Keiko ; Hartley, Janet W. ; Taylor, Benjamin A. ; Ward, Jerrold M. ; Jenkins, Nancy A. ; Copeland, Neal G. ; Fredrickson, Torgny N. / Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice. In: Leukemia Research. 2001 ; Vol. 25, No. 8. pp. 719-733.

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abstract = "Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V+ and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.",

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AU - Taddesse-Heath, Lekidelu

AU - Ozato, Keiko

AU - Hartley, Janet W.

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AU - Copeland, Neal G.

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AB - Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V+ and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.

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KW - Mouse B-cell lymphoma

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KW - Proviral insertional mutagenesis

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