Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.

Original languageEnglish (US)
Article number1826
Issue number8
StatePublished - Jul 29 2022


  • adult
  • cholangiocarcinoma
  • combined hepatocellular-cholangiocarcinoma
  • hepatocellular carcinoma
  • liver cancers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)


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