Combined effects of ticarcillin and cefazolin on blood coagulation and platelet function

E. A. Natelson; W. T. Siebert; T. W. Williams; M. W. Bradshaw

doi:10.1097/00000441-197911000-00005

Combined effects of ticarcillin and cefazolin on blood coagulation and platelet function

E. A. Natelson, W. T. Siebert, T. W. Williams, M. W. Bradshaw

Research output: Contribution to journal › Article › peer-review

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Abstract

Combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component. No effect on soluble blood coagulation factors was evident. Acute administration of corticosteroids did not influence the prolonged bleeding times induced by extended ticarcillin infusions.

Original language	English (US)
Pages (from-to)	217-221
Number of pages	5
Journal	American Journal of the Medical Sciences
Volume	278
Issue number	3
DOIs	https://doi.org/10.1097/00000441-197911000-00005
State	Published - 1979

ASJC Scopus subject areas

General Medicine

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title = "Combined effects of ticarcillin and cefazolin on blood coagulation and platelet function",

abstract = "Combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component. No effect on soluble blood coagulation factors was evident. Acute administration of corticosteroids did not influence the prolonged bleeding times induced by extended ticarcillin infusions.",

author = "Natelson, {E. A.} and Siebert, {W. T.} and Williams, {T. W.} and Bradshaw, {M. W.}",

year = "1979",

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AU - Natelson, E. A.

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AU - Williams, T. W.

AU - Bradshaw, M. W.

PY - 1979

Y1 - 1979

N2 - Combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component. No effect on soluble blood coagulation factors was evident. Acute administration of corticosteroids did not influence the prolonged bleeding times induced by extended ticarcillin infusions.

AB - Combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component. No effect on soluble blood coagulation factors was evident. Acute administration of corticosteroids did not influence the prolonged bleeding times induced by extended ticarcillin infusions.

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Combined effects of ticarcillin and cefazolin on blood coagulation and platelet function

Abstract

ASJC Scopus subject areas

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