Combined effect of terbutaline and betamethasone on glucose homeostasis in preterm labor

Karolina Adam, C. N. Ou, D. B. Cotton

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The short- and long-term effects of simultaneous administration of terbutaline and betamethasone were investigated in 8 gravidas treated for preterm labor. Their plasma concentrations of glucose, insulin, glucagon, C- peptide, lactate and potassium were compared to a control group receiving intravenous magnesium sulfate and betamethasone. The patients on terbutaline therapy had a marked hyperglycemia at 11 h which remained elevated for 48 h. There was a simultaneous rise in plasma insulin and C-peptide, and a fall in plasma glucagon. Lactate levels were markedly elevated. Only 1 of the 8 patients had an abnormal glucose tolerance test at 1 week of therapy. The metabolic changes of control patients were minimal in comparison and there was no lacticacidemia. This suggests that glucocorticoids potentiate the hyperglycemic response of terbutaline.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalFetal Diagnosis and Therapy
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Combined effect of terbutaline and betamethasone on glucose homeostasis in preterm labor'. Together they form a unique fingerprint.

Cite this