Combined cutting balloon angioplasty and intracoronary beta radiation for treatment of in-stent restenosis: Clinical outcomes and effect of pullback radiation for long lesions

Ali Moustapha, Joseph Salloum, Sangeeta Saikia, Hany Awadallah, Mohammed Ghani, Stefano Sdringola, George Schroth, Abid Assali, Richard W. Smalling, H. V. Anderson, Oscar Rosales

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Intracoronary beta (β) radiation decreases the incidence of target lesion revascularization after percutaneous intervention (PCI) for in-stent restenosis (ISR). Cutting balloon (CB) angioplasty may also be superior to other percutaneous techniques for the treatment of ISR. We sought to study the outcomes of patients with ISR who underwent both CB angioplasty and intracoronay β radiation and compare them to patients with ISR who underwent other PCI techniques without concomitant radiation. We also sought to evaluate the safety and efficacy of pullback intracoronary β radiation for the treatment of long ISR lesions. Between January 2001 and November 2001, 102 patients (mean age = 55 ± 13 years) with ISR underwent both CB angioplasty and intracoronay β radiation. β radiation was delivered using the Beta Cath (Novoste) 30 mm system, and pullback radiation was performed in 41 patients. A comparison group included a total of 393 patients with ISR who underwent other PCI techniques without concomitant intracoronary radiation therapy. Follow-up was obtained in 99 patients (97%) in the CB angioplasty with intracoronary radiation group and 377 patients (96%) in the comparison group. At follow-up, both target vessel revascularization (TVR) and major adverse cardiovascular events (MACE) occurred significantly less in the CB angioplasty with intracoronary radiation group than in the comparison group (7% vs. 18% for TVR, and 14% vs. 24% for MACE; P < 0.05 for both). In the pullback radiation group, TVR was performed in five patients (12%), and MACE occurred in eight patients (20%). A combination of CB angioplasty and intracoronay β radiation for ISR seems to yield low rates of subsequent target vessel revascularization and adverse cardiac events. In addition, pullback β radiation using the Beta Cath (Novoste) 30 mm system is safe and can be used to treat long ISR lesions effectively. Further randomized trials are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume57
Issue number3
DOIs
StatePublished - Nov 1 2002

Keywords

  • Brachytherapy
  • Cutting balloon
  • Restenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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