Combined chemokine and cytokine gene transfer enhances antitumor immunity

Dagmar Dilloo, Kevin Bacon, William Holden, Wanyun Zhong, Stefan Burdach, Albert Zlotnik, Malcolm Brenner

Research output: Contribution to journalArticle

187 Scopus citations

Abstract

The probability of producing a specific antitumor response should be increased by multiplying the number of T lymphocytes that encounter the malignant cells. We tested this prediction in a murine model, using a recently discovered T-cell chemokine, lymphotactin (Lptn). This chemokine increased tumor cell infiltration with CD4+ lymphocytes but generated little antitumor activity. Coexpression of the T-cell growth factor interleukin-2 however, greatly expanded the T lymphocytes attracted by Lptn, affording protection from the growth of established tumor in a CD4+ and CD8+ T cell-dependent manner. Lesser synergy was seen with GM-CSF. Hence coexpression of a T-cell chemokine and T-cell growth factor potentiates antitumor responses in vivo, suggesting a general strategy to improve cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)1090-1095
Number of pages6
JournalNature Medicine
Volume2
Issue number10
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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