Combined Antimicrobial Therapy for Infective Endocarditis

Sara I. Gomez-Villegas; William R. Miller; Cesar A. Arias

doi:10.1007/978-3-031-65839-6_16

Combined Antimicrobial Therapy for Infective Endocarditis

Sara I. Gomez-Villegas, William R. Miller, Cesar A. Arias

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Despite the availability of potent antimicrobials and more aggressive and safer surgical procedures, the management of infective endocarditis remains difficult. The present chapter focuses on the in vitro, in vivo, and clinical evidence regarding the use of combination antibiotic therapy for the more common pathogens causing infective endocarditis, namely S. aureus, streptococci, and enterococci. We aim to discuss the molecular and biological rationale for combination therapies, as well as the potential pitfalls and toxicities of different approaches that encompass the use of multiple agents. We present a comprehensive review on the use of combined antimicrobial therapy in order to provide safe and effective management of difficult to treat Gram-positive infections in the setting of infective endocarditis.

Original language	English (US)
Title of host publication	Infective Endocarditis
Subtitle of host publication	A Multidisciplinary Team Approach to a Complex Disease
Publisher	Springer Science+Business Media
Pages	199-256
Number of pages	58
ISBN (Electronic)	9783031658396
ISBN (Print)	9783031658389
DOIs	https://doi.org/10.1007/978-3-031-65839-6_16
State	Published - Jan 1 2025

Keywords

Aminoglycosides
Antimicrobial resistance
Combination therapy
Enterococci
In vitro studies
In vivo models
Infective Endocarditis
Staphylococci
Streptococci
Synergism
Toxicity
β-lactam antibiotics

ASJC Scopus subject areas

General Medicine
General Neuroscience

Divisions

Infectious Disease

Access to Document

10.1007/978-3-031-65839-6_16

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abstract = "Despite the availability of potent antimicrobials and more aggressive and safer surgical procedures, the management of infective endocarditis remains difficult. The present chapter focuses on the in vitro, in vivo, and clinical evidence regarding the use of combination antibiotic therapy for the more common pathogens causing infective endocarditis, namely S. aureus, streptococci, and enterococci. We aim to discuss the molecular and biological rationale for combination therapies, as well as the potential pitfalls and toxicities of different approaches that encompass the use of multiple agents. We present a comprehensive review on the use of combined antimicrobial therapy in order to provide safe and effective management of difficult to treat Gram-positive infections in the setting of infective endocarditis.",

keywords = "Aminoglycosides, Antimicrobial resistance, Combination therapy, Enterococci, In vitro studies, In vivo models, Infective Endocarditis, Staphylococci, Streptococci, Synergism, Toxicity, β-lactam antibiotics",

author = "Gomez-Villegas, \{Sara I.\} and Miller, \{William R.\} and Arias, \{Cesar A.\}",

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AU - Miller, William R.

AU - Arias, Cesar A.

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Despite the availability of potent antimicrobials and more aggressive and safer surgical procedures, the management of infective endocarditis remains difficult. The present chapter focuses on the in vitro, in vivo, and clinical evidence regarding the use of combination antibiotic therapy for the more common pathogens causing infective endocarditis, namely S. aureus, streptococci, and enterococci. We aim to discuss the molecular and biological rationale for combination therapies, as well as the potential pitfalls and toxicities of different approaches that encompass the use of multiple agents. We present a comprehensive review on the use of combined antimicrobial therapy in order to provide safe and effective management of difficult to treat Gram-positive infections in the setting of infective endocarditis.

AB - Despite the availability of potent antimicrobials and more aggressive and safer surgical procedures, the management of infective endocarditis remains difficult. The present chapter focuses on the in vitro, in vivo, and clinical evidence regarding the use of combination antibiotic therapy for the more common pathogens causing infective endocarditis, namely S. aureus, streptococci, and enterococci. We aim to discuss the molecular and biological rationale for combination therapies, as well as the potential pitfalls and toxicities of different approaches that encompass the use of multiple agents. We present a comprehensive review on the use of combined antimicrobial therapy in order to provide safe and effective management of difficult to treat Gram-positive infections in the setting of infective endocarditis.

KW - Aminoglycosides

KW - Antimicrobial resistance

KW - Combination therapy

KW - Enterococci

KW - In vitro studies

KW - In vivo models

KW - Infective Endocarditis

KW - Staphylococci

KW - Streptococci

KW - Synergism

KW - Toxicity

KW - β-lactam antibiotics

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M3 - Chapter

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BT - Infective Endocarditis

PB - Springer Science+Business Media

ER -

Combined Antimicrobial Therapy for Infective Endocarditis

Abstract

Keywords

ASJC Scopus subject areas

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