Abstract
Background: – Godtfredsen syndrome (GS), originally described by Dr. Erik Godtfredsen in 1946, is the combination of cranial nerve (CN) 6th and 12th palsies. The most common etiology of GS is a lesion of the clivus.Methods: – A retrospective case series of GS is described.Results: – Three patients were included: 1) a 38-year-old woman with a clival breast cancer metastasis; 2) a 35-year-old woman with a clival chordoma; and 3) a 72-year-old woman with a partially embolized dural arteriovenous fistula involving the hypoglossal canal.Conclusions: – GS is a combination of CN 6th and 12th palsies and most commonly is due to a lesion in the clivus. Clinicians should be aware of this uncommon combination of cranial nerve findings, the localizing significance, and the differential diagnosis of clival lesions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 18-21 |
| Number of pages | 4 |
| Journal | Journal of Neuro-Ophthalmology |
| Volume | 46 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2026 |
Keywords
- Humans
- Female
- Aged
- Adult
- Cranial Fossa, Posterior/pathology
- Abducens Nerve Diseases/etiology
- Skull Base Neoplasms/complications
- Retrospective Studies
- Magnetic Resonance Imaging
- Trochlear Nerve Diseases/etiology
- Chordoma/complications
- Breast Neoplasms/pathology
- Cranial Nerve Diseases/etiology
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology
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