TY - JOUR
T1 - Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
AU - Harris, R. Alan
AU - Shah, Rajesh
AU - Hollister, Emily B.
AU - Tronstad, Rune Rose
AU - Hovdenak, Nils
AU - Szigeti, Reka
AU - Versalovic, James
AU - Kellermayer, Richard
N1 - Publisher Copyright:
© 2016 R. Alan Harris et al.
PY - 2016
Y1 - 2016
N2 - Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.
AB - Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.
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U2 - 10.1155/2016/9170162
DO - 10.1155/2016/9170162
M3 - Article
C2 - 27006956
AN - SCOPUS:84960983840
SN - 2314-8861
VL - 2016
JO - Journal of Immunology Research
JF - Journal of Immunology Research
M1 - 9170162
ER -