Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

R. Alan Harris; Rajesh Shah; Emily B. Hollister; Rune Rose Tronstad; Nils Hovdenak; Reka Szigeti; James Versalovic; Richard Kellermayer

doi:10.1155/2016/9170162

Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

R. Alan Harris, Rajesh Shah, Emily B. Hollister, Rune Rose Tronstad, Nils Hovdenak, Reka Szigeti, James Versalovic, Richard Kellermayer

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.

Original language	English (US)
Article number	9170162
Journal	Journal of Immunology Research
Volume	2016
DOIs	https://doi.org/10.1155/2016/9170162
State	Published - 2016

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents",

abstract = "Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.",

author = "Harris, {R. Alan} and Rajesh Shah and Hollister, {Emily B.} and Tronstad, {Rune Rose} and Nils Hovdenak and Reka Szigeti and James Versalovic and Richard Kellermayer",

note = "Funding Information: Richard Kellermayer would like to acknowledge the Gutsy Kids Fund including philanthropic donation from the Karen and Brock Wagner family and the Houston Men of Distinction for their generous support. The authors also acknowledge support from the NIH for the Texas Medical Center Digestive Diseases Center (P30 DK56338). Publisher Copyright: {\textcopyright} 2016 R. Alan Harris et al.",

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journal = "Journal of Immunology Research",

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AU - Harris, R. Alan

AU - Shah, Rajesh

AU - Hollister, Emily B.

AU - Tronstad, Rune Rose

AU - Hovdenak, Nils

AU - Szigeti, Reka

AU - Versalovic, James

AU - Kellermayer, Richard

N1 - Funding Information: Richard Kellermayer would like to acknowledge the Gutsy Kids Fund including philanthropic donation from the Karen and Brock Wagner family and the Houston Men of Distinction for their generous support. The authors also acknowledge support from the NIH for the Texas Medical Center Digestive Diseases Center (P30 DK56338). Publisher Copyright: © 2016 R. Alan Harris et al.

PY - 2016

Y1 - 2016

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AB - Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.

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Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

Abstract

ASJC Scopus subject areas

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