Collagenous enterocolitis: A manifestation of gluten-sensitive enteropathy

T. M. McCashland, J. P. Donovan, R. S. Strobach, J. Linder, Eamonn Martin Quigley

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


We report coexistent collagenous colitis and collagenous sprue in a 62- year-old woman with diarrhea. Investigations suggested malabsorption, and small intestinal biopsies demonstrated a flattened mucosa with subepithelial collagen deposition. Colonic biopsies also showed a thickened subepithelial collagen band as well as a striking lamina propria inflammatory cell infiltrate. Symptomatic remission was induced with a gluten/lactose-free diet, oral prednisone, and sulfasalazine and has been maintained with gluten restriction alone. Repeat biopsies after 2 months demonstrated restoration of normal small intestinal and colonic collagen bands; only a chronic inflammatory cell infiltrate (consistent with microscopic/lymphocytic colitis) persisted in colonic biopsies. We propose that, in this instance, collagenous enterocolitis represented a diffuse manifestation of gluten sensitivity.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalJournal of Clinical Gastroenterology
Issue number1
StatePublished - Jan 1 1992


  • Celiac sprue
  • Collagenous colitis
  • Collagenous enterocolitis
  • Gluten-sensitive enteropathy
  • Lymphocytic colitis
  • Microscopic colitis
  • Sprue

ASJC Scopus subject areas

  • Gastroenterology


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