Collagenase and surgical disease

Timothy R. Donahue, Jonathan R. Hiatt, Ronald W. Busuttil

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Collagen types I, II, and III are the most abundant extracellular matrix (ECM) proteins. Collagenase is a member of the matrix metalloproteinase (MMP) family of enzymes, and is the principal enzyme involved with collagen degradation. Cellular-ECM interactions are vitally important to tissue structure and function. In this review, we summarize recent work that highlights the role of collagenase in ECM remodeling and repair, and further report that alterations of collagenase expression, function, and/or regulation are found in many diverse disease states, including aortic aneurysms, tumor invasiveness and their metastases, and hernias. Collagenase is intimately involved in many surgical diseases, and represents a potential target for therapy.

Original languageEnglish (US)
Pages (from-to)478-485
Number of pages8
JournalHernia
Volume10
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • Aneurysm
  • Collagenase
  • Hernia
  • Matrix metalloproteinase
  • Wound healing

ASJC Scopus subject areas

  • Surgery

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