Cold-insoluble globulin mediates the adhesion of rat liver cells to plastic petri dishes

Magnus Hook, Kristofer Rubin, Åke Oldberg, Björn Öbrink, Antti Vaheri

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Adhesion of rat hepatocytes to plastic culture dishes requires a factor present in normal plasma or serum which tentatively is identified as cold-insoluble globulin since (i) cold-insoluble globulin was the only native plasma protein tested showing cell-adhesion mediating activity, and (ii) plasma from which cold-insoluble globulin selectively had been removed lost its ability to induce cell attachment. Under certain circumstances also asialoceruloplasmin became a potent cell adhesion mediating agent. However, cell attachment mediated by asialoceruloplasmin and cold-insoluble globulin, respectively, was demonstrated to involve separate mechanisms.

Original languageEnglish (US)
Pages (from-to)726-733
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Dec 7 1977

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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