Adhesion of rat hepatocytes to plastic culture dishes requires a factor present in normal plasma or serum which tentatively is identified as cold-insoluble globulin since (i) cold-insoluble globulin was the only native plasma protein tested showing cell-adhesion mediating activity, and (ii) plasma from which cold-insoluble globulin selectively had been removed lost its ability to induce cell attachment. Under certain circumstances also asialoceruloplasmin became a potent cell adhesion mediating agent. However, cell attachment mediated by asialoceruloplasmin and cold-insoluble globulin, respectively, was demonstrated to involve separate mechanisms.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Dec 7 1977|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology