Coinfection with hepatitis C virus increases lymphocyte apoptosis in HIV-infected patients

Marina Núñez; Vincent Soriano; Mariola López; Celia Ballesteros; Almudena Cascajero; Juan González-Lahoz; Jose Miguel Benito

doi:10.1086/508355

Coinfection with hepatitis C virus increases lymphocyte apoptosis in HIV-infected patients

Marina Núñez, Vincent Soriano, Mariola López, Celia Ballesteros, Almudena Cascajero, Juan González-Lahoz, Jose Miguel Benito

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4⁺ T cells and in naive and memory CD8⁺ T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.

Original language	English (US)
Pages (from-to)	1209-1212
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	43
Issue number	9
DOIs	https://doi.org/10.1086/508355
State	Published - Nov 1 2006

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/508355

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abstract = "To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4+ T cells and in naive and memory CD8+ T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.",

author = "Marina N{\'u}{\~n}ez and Vincent Soriano and Mariola L{\'o}pez and Celia Ballesteros and Almudena Cascajero and Juan Gonz{\'a}lez-Lahoz and Benito, {Jose Miguel}",

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AU - Núñez, Marina

AU - Soriano, Vincent

AU - López, Mariola

AU - Ballesteros, Celia

AU - Cascajero, Almudena

AU - González-Lahoz, Juan

AU - Benito, Jose Miguel

PY - 2006/11/1

Y1 - 2006/11/1

N2 - To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4+ T cells and in naive and memory CD8+ T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.

AB - To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4+ T cells and in naive and memory CD8+ T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.

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Coinfection with hepatitis C virus increases lymphocyte apoptosis in HIV-infected patients

Abstract

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