TY - JOUR
T1 - Cognitive Deficits in Asymptomatic First-Degree Relatives of Alzheimer's Disease Patients
AU - Hom, Jim
AU - Turner, Mary B.
AU - Risser, Richard
AU - Bonte, Frederick J.
AU - Tintner, Ron
N1 - Funding Information:
* Supported in part by grants from the National Institute of Aging (5 P50 AG08013) and National Institute of Health (2 SO7 RR05426-29 BRSG). The authors gratefully acknowledge the assistance of Drs. Myron Weiner and Roger Rosenberg in the neurological and medical diagnoses of the subjects used in this study; nurses Doris Svetlik and Teresa Riall, and Jackie Rabb in the coordination of patient and medical services; technicians Kier Bison, Ruth Boring, Christina Darby, Carrie Molho, and Judy Shaw for the neuropsychological testing of the subjects; and Dr. Janice Nici for her thoughtful review of the manuscript. The authors also thank the relatives, families, and friends who generously gave their time to participate in the study. This research was conducted while the first author was at the University of Texas Southwestern Medical Center, Dallas, Texas. Address reprint requests to Dr. Jim Hom, The Neuropsychology Center, 9400 North Central Expressway, Suite 904, Dallas, TX, 7523 1, USA. Accepted for publication: September 22, 1993.
PY - 1994/8/1
Y1 - 1994/8/1
N2 - The present study was designed to determine whether neuropsychological deficits exist in asymptomatic first-degree relatives of Alzheimer's disease (AD) patients. The neuropsychological performances of 20 first-degree asymptomatic relatives of NINCDS-ADRDA diagnosed AD patients were compared to 20 normal controls without family history of AD. Cognitive functions assessed included intelligence, memory, overall brain function, verbal learning, and language and constructional abilities. Significant statistical differences were found between the groups across several cognitive areas indicating lower functioning in the first-degree relatives of AD patients. Fifty percent of the first-degree subjects but only 20% of controls showed a pattern of significant neuropsychological deficit. The results demonstrate neuropsychological deficits in asymptomatic first-degree relatives of AD patients, suggesting that preclinical markers for AD may be present long before the clinical manifestation of the disease.
AB - The present study was designed to determine whether neuropsychological deficits exist in asymptomatic first-degree relatives of Alzheimer's disease (AD) patients. The neuropsychological performances of 20 first-degree asymptomatic relatives of NINCDS-ADRDA diagnosed AD patients were compared to 20 normal controls without family history of AD. Cognitive functions assessed included intelligence, memory, overall brain function, verbal learning, and language and constructional abilities. Significant statistical differences were found between the groups across several cognitive areas indicating lower functioning in the first-degree relatives of AD patients. Fifty percent of the first-degree subjects but only 20% of controls showed a pattern of significant neuropsychological deficit. The results demonstrate neuropsychological deficits in asymptomatic first-degree relatives of AD patients, suggesting that preclinical markers for AD may be present long before the clinical manifestation of the disease.
UR - https://www.scopus.com/pages/publications/0028247058
UR - https://www.scopus.com/inward/citedby.url?scp=0028247058&partnerID=8YFLogxK
U2 - 10.1080/01688639408402668
DO - 10.1080/01688639408402668
M3 - Article
C2 - 7962359
AN - SCOPUS:0028247058
SN - 1380-3395
VL - 16
SP - 568
EP - 576
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 4
ER -