TY - JOUR
T1 - Cognition in individuals at risk for Parkinson's
T2 - Parkinson associated risk syndrome (PARS) study findings
AU - PARS Investigators
AU - Chahine, Lama M.
AU - Weintraub, Daniel
AU - Hawkins, Keith A.
AU - Siderowf, Andrew
AU - Eberly, Shirley
AU - Oakes, David
AU - Seibyl, John
AU - Stern, Matthew B.
AU - Marek, Kenneth
AU - Jennings, Danna
AU - Russell, David
AU - Fiocco, Abby
AU - Sethi, Kapil
AU - Jackson, Paula
AU - Frank, Samuel
AU - Thomas, Cathi A.
AU - James, Raymond C.
AU - Simuni, Tanya
AU - Borushko, Emily
AU - Stern, Matt
AU - Rick, Jacqueline
AU - Hauser, Robert
AU - Khavarian, Leyla
AU - Richard, Irene
AU - Deeley, Cheryl
AU - Liang, Grace S.
AU - Infeld, Liza
AU - Adler, Charles H.
AU - Duffy, Amy K.
AU - Saunders-Pullman, Rachel
AU - Evatt, Marian L.
AU - McMurray, Becky
AU - Lai, Eugene
AU - Johnson, Shawna
AU - DeBakey, Michael E.
AU - Subramanian, Indu
AU - Gratiano, Angelina
AU - Chung, Kathryn
AU - Lobb, Brenna
AU - O'Conner, Susan
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objectives: The Parkinson Associated Risk Syndrome Study identified a cohort of healthy adults with hyposmia and dopamine transporter binding reduction to characterize individuals at risk for Parkinson's disease (PD). We describe the cognitive profile of this cohort. Methods: Individuals older than 50 y without PD were recruited. Two hundred twenty-five completed cognitive testing and were included in the final analysis. A neuropsychological test battery was administered and normative scores created for global cognition, memory, executive function/working memory, processing speed/attention, visuospatial abilities, and language domains. Other non-motor symptoms (constipation, depression, anxiety, and rapid eye movement sleep behavior disorder) were assessed through questionnaires. Results: Individuals with both hyposmia and reduced dopamine transporter binding (n=38) had lower mean scores for global cognition, executive function/working memory, and memory compared with all other participants (n=187). In separate multivariate logistic regression models, lower global cognition (odds ratio, 1.97, P=0.004), and specifically executive function/working memory (odds ratio, 1.84, P=0.004) scores were associated with membership in the hyposmia with dopamine transporter reduction group. Combining hyposmia with relative impairment on specific cognitive domains increased the odds of dopamine transporter binding reduction compared with hyposmia alone, with the greatest increase in odds for hyposmia plus executive function/working memory relative impairment (68% increase in odds from 4.14 to 6.96). Conclusion: Changes in global cognitive abilities, and specifically executive function/working memory, are present in individuals at risk for PD. Combining non-motor features, including cognition, improves prediction of dopamine transporter binding reduction.
AB - Objectives: The Parkinson Associated Risk Syndrome Study identified a cohort of healthy adults with hyposmia and dopamine transporter binding reduction to characterize individuals at risk for Parkinson's disease (PD). We describe the cognitive profile of this cohort. Methods: Individuals older than 50 y without PD were recruited. Two hundred twenty-five completed cognitive testing and were included in the final analysis. A neuropsychological test battery was administered and normative scores created for global cognition, memory, executive function/working memory, processing speed/attention, visuospatial abilities, and language domains. Other non-motor symptoms (constipation, depression, anxiety, and rapid eye movement sleep behavior disorder) were assessed through questionnaires. Results: Individuals with both hyposmia and reduced dopamine transporter binding (n=38) had lower mean scores for global cognition, executive function/working memory, and memory compared with all other participants (n=187). In separate multivariate logistic regression models, lower global cognition (odds ratio, 1.97, P=0.004), and specifically executive function/working memory (odds ratio, 1.84, P=0.004) scores were associated with membership in the hyposmia with dopamine transporter reduction group. Combining hyposmia with relative impairment on specific cognitive domains increased the odds of dopamine transporter binding reduction compared with hyposmia alone, with the greatest increase in odds for hyposmia plus executive function/working memory relative impairment (68% increase in odds from 4.14 to 6.96). Conclusion: Changes in global cognitive abilities, and specifically executive function/working memory, are present in individuals at risk for PD. Combining non-motor features, including cognition, improves prediction of dopamine transporter binding reduction.
KW - Cognition
KW - Dopaminergic deficit
KW - Hyposmia
KW - Parkinson's
KW - Prodromal
UR - http://www.scopus.com/inward/record.url?scp=84956720438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84956720438&partnerID=8YFLogxK
U2 - 10.1002/mds.26373
DO - 10.1002/mds.26373
M3 - Article
C2 - 26293177
AN - SCOPUS:84956720438
VL - 31
SP - 86
EP - 94
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 1
ER -