Coexistence of c-Fos and glucocorticoid receptor immunoreactivities in the CRF immunoreactive neurons of the paraventricular hypothalamic nucleus of the rat after acute immobilization stress

Rafael Coveñas, Mercedes de León, Antonio Cintra, Börje Bjelke, Jan Åke Gustafsson, Kjell Fuxe

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

By means of triple immunofluorescence procedures the codistribution and coexistence of glucocorticoid receptor (GR), c-Fos and corticotropin-releasing factor (CRF) immunoreactive (IR) nerve cell profiles have been analyzed within the paraventricular hypothalamic nucleus at various rostrocaudal levels following acute immobilization stress (2 h) in the male rat. One population of CRF IR neurons is shown to contain both nuclear GR and c-Fos immunoreactivities following the stress, while another contains GR immunoreactivity alone. These results indicate heterogeneities among parvocellular CRF paraventricular hypothalamic nerve cell populations in the response to acute immobilization stress.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalNeuroscience Letters
Volume149
Issue number2
DOIs
StatePublished - Jan 12 1993

Keywords

  • Corticotropin-releasing hormone
  • Double and triple immunofluorescence procedure
  • Glucocorticoid receptor
  • Paraventricular hypothalamic nucleus
  • Proto-oncogene

ASJC Scopus subject areas

  • Neuroscience(all)

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