Cocaine Intoxication

Janice L. Zimmerman

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can affect all body systems and the clinical presentation may primarily result from organ toxicity. Among the most severe complications are seizures, hemorrhagic and ischemic strokes, myocardial infarction, aortic dissection, rhabdomyolysis, mesenteric ischemia, acute renal injury and multiple organ failure.

Original languageEnglish (US)
Pages (from-to)517-526
Number of pages10
JournalCritical Care Clinics
Volume28
Issue number4
DOIs
StatePublished - Oct 2012

Keywords

  • Acute coronary syndrome
  • Chest pain
  • Cocaine
  • Hyperthermia
  • Intracranial hemorrhage
  • Rhabdomyolysis
  • Stroke

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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