Clustered p53 immunostaining: A novel pattern associated with prostate cancer progression

Guang Yang, Alan M.F. Stapleton, Thomas M. Wheeler, Luan Truong, Terry L. Timme, Peter T. Scardino, Timothy C. Thompson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Abnormal p53 protein accumulation is typically defined as present when greater than 5 or 10% of cancer cells stain positively. We present a novel approach whereby immunopositivity is defined when 15 or more cells within a 300 x 400-μm2 field exhibit p53 protein accumulation; a feature that we have called 'clustered' staining. We assessed p53 immunostaining of moderately differentiated, clinically localized prostate cancers derived from two patient groups: those without cancer recurrence 5 years after radical prostatectomy, and those in whom cancer had recurred following radical prostatectomy. Clustered p53 immunopositivity was present in 10 (63%) of 16 patients in the recurrent group and in only 7 (21%) of 33 in the nonrecurrent group. Clustered p53 staining was clearly associated with cancer recurrence (P < 0.01). This refinement of a commonly used assay may help define the biological aggressiveness of a cancer.

Original languageEnglish (US)
Pages (from-to)399-401
Number of pages3
JournalClinical Cancer Research
Volume2
Issue number2
StatePublished - 1996

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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