Clotting factors to treat thrombolysis-related symptomatic intracranial hemorrhage in acute ischemic stroke

Yazan J. Alderazi, Niravkumar V. Barot, Hui Peng, Farhaan S. Vahidy, Digvijaya D. Navalkele, Navdeep Sangha, Vivek Misra, Sean I. Savitz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background Symptomatic intracranial hemorrhage (sICH) occurs uncommonly after ischemic stroke therapy with tissue plasminogen activator (tPA). Clotting factor administration may be a treatment option. Objective To determine if treatment with clotting factors (fresh frozen plasma [FFP] or cryoprecipitate) was associated with improved outcomes in sICH. Methods We conducted a retrospective cohort study within University of Texas at Houston Stroke registry involving consecutive patients from February 1, 2007, to June 30, 2011, with tPA-related sICH, including cases with subsequent intra-arterial therapy. Outcomes were Modified Rankin Scale (mRS) score at discharge, death, and hematoma expansion. Results Of 921 patients treated with tPA, 48 (5.2%) had sICH and 45 met criteria for the study. Nineteen patients received clotting factors (42.2%; 18 received FFP and 7 received cryoprecipitate), whereas 26 (57.8%) patients received conservative management without clotting factors. None of the patients treated with clotting factors and only 2 of those who did not receive clotting factors had a good outcome, mRS score of 2 or less. All the patients treated with clotting factors and most of those not treated were left bedridden or dead (mRS score 4-6), 19 (100%) versus 22 (85%). Mortality was 9 (47.4%) versus 9 (34.6%), respectively. There was no difference in hematoma expansion between the 2 groups. Conclusions We found no evidence that treatment for sICH with clotting factors has a favorable effect on clinical or radiological outcomes. However, the sample was small because of the low frequency of sICH. New treatments are urgently needed for this uncommon yet serious condition.

Original languageEnglish (US)
Pages (from-to)e207-e214
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number3
StatePublished - Mar 2014


  • Cerebrovascular disease
  • acute ischemic stroke
  • fresh frozen plasma
  • stroke
  • symptomatic intracranial hemorrhage
  • thrombolysis

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Clotting factors to treat thrombolysis-related symptomatic intracranial hemorrhage in acute ischemic stroke'. Together they form a unique fingerprint.

Cite this