Clopidogrel use as a risk factor for poor outcomes after kidney transplantation

Jennifer M. Williams; Janet E. Tuttle-Newhall; Mark Schnitzler; Nino Dzebisashvili; Huiling Xiao; David Axelrod; Harveshp Mogal; Krista L. Lentine

doi:10.1016/j.amjsurg.2014.06.007

Clopidogrel use as a risk factor for poor outcomes after kidney transplantation

Jennifer M. Williams, Janet E. Tuttle-Newhall, Mark Schnitzler, Nino Dzebisashvili, Huiling Xiao, David Axelrod, Harveshp Mogal, Krista L. Lentine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background

Methods:

Results: Clopidogrel fills within 90 days of transplant were associated with 61% of increased relative mortality risk and 23% of increased graft failure risk. Risks were higher in those whose last clopidogrel fill was more than 90 days before transplantation (111% for death, 59% for graft loss).

Conclusions: Clopidogrel use before kidney transplantation portends increased risks of post-transplant death and graft loss. Pharmacy claims may identify novel prognostic markers not currently captured in the transplant registry.

Original language	English (US)
Pages (from-to)	556-562
Number of pages	7
Journal	American Journal of Surgery
Volume	208
Issue number	4
DOIs	https://doi.org/10.1016/j.amjsurg.2014.06.007
State	Published - Oct 1 2014

Keywords

Clopidogrel Death Graft loss Kidney transplantation Outcomes Pharmacy records

ASJC Scopus subject areas

Surgery

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10.1016/j.amjsurg.2014.06.007

Cite this

@article{d962cb295cfe43efa036169dc49fdb82,

title = "Clopidogrel use as a risk factor for poor outcomes after kidney transplantation",

abstract = "BackgroundMethods:Results: Clopidogrel fills within 90 days of transplant were associated with 61\% of increased relative mortality risk and 23\% of increased graft failure risk. Risks were higher in those whose last clopidogrel fill was more than 90 days before transplantation (111\% for death, 59\% for graft loss).Conclusions: Clopidogrel use before kidney transplantation portends increased risks of post-transplant death and graft loss. Pharmacy claims may identify novel prognostic markers not currently captured in the transplant registry.",

keywords = "Clopidogrel Death Graft loss Kidney transplantation Outcomes Pharmacy records",

author = "Williams, \{Jennifer M.\} and Tuttle-Newhall, \{Janet E.\} and Mark Schnitzler and Nino Dzebisashvili and Huiling Xiao and David Axelrod and Harveshp Mogal and Lentine, \{Krista L.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

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day = "1",

doi = "10.1016/j.amjsurg.2014.06.007",

language = "English (US)",

volume = "208",

pages = "556--562",

journal = "American Journal of Surgery",

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TY - JOUR

T1 - Clopidogrel use as a risk factor for poor outcomes after kidney transplantation

AU - Williams, Jennifer M.

AU - Tuttle-Newhall, Janet E.

AU - Schnitzler, Mark

AU - Dzebisashvili, Nino

AU - Xiao, Huiling

AU - Axelrod, David

AU - Mogal, Harveshp

AU - Lentine, Krista L.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - BackgroundMethods:Results: Clopidogrel fills within 90 days of transplant were associated with 61% of increased relative mortality risk and 23% of increased graft failure risk. Risks were higher in those whose last clopidogrel fill was more than 90 days before transplantation (111% for death, 59% for graft loss).Conclusions: Clopidogrel use before kidney transplantation portends increased risks of post-transplant death and graft loss. Pharmacy claims may identify novel prognostic markers not currently captured in the transplant registry.

AB - BackgroundMethods:Results: Clopidogrel fills within 90 days of transplant were associated with 61% of increased relative mortality risk and 23% of increased graft failure risk. Risks were higher in those whose last clopidogrel fill was more than 90 days before transplantation (111% for death, 59% for graft loss).Conclusions: Clopidogrel use before kidney transplantation portends increased risks of post-transplant death and graft loss. Pharmacy claims may identify novel prognostic markers not currently captured in the transplant registry.

KW - Clopidogrel Death Graft loss Kidney transplantation Outcomes Pharmacy records

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DO - 10.1016/j.amjsurg.2014.06.007

M3 - Article

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AN - SCOPUS:84908126549

SN - 0002-9610

VL - 208

SP - 556

EP - 562

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 4

ER -

Clopidogrel use as a risk factor for poor outcomes after kidney transplantation

Abstract

Keywords

ASJC Scopus subject areas

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