Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases

Nian Zhang; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Thomas Gridley

doi:10.1006/geno.1999.6055

Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases

Nian Zhang, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Thomas Gridley

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Abstract

The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	142-144
Number of pages	3
Journal	Genomics
Volume	63
Issue number	1
DOIs	https://doi.org/10.1006/geno.1999.6055
State	Published - Jan 1 2000

ASJC Scopus subject areas

Genetics

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title = "Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases",

abstract = "The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. (C) 2000 Academic Press.",

author = "Nian Zhang and Copeland, \{Neal G.\} and Gilbert, \{Debra J.\} and Jenkins, \{Nancy A.\} and Thomas Gridley",

note = "Funding Information: We thank D. Householder for technical assistance and W. Frankel and T. O{\textquoteright}Brien for comments on the manuscript. This work was supported by grants from the NIH (RO1NS36437 and RO1HD34883) to T.G. and by a grant (CA34196) from the National Cancer Institute to The Jackson Laboratory. Research at the Frederick Cancer Research and Development Center was supported by the National Cancer Institute, DHHS, under contract with ABL.",

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doi = "10.1006/geno.1999.6055",

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T1 - Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases

AU - Zhang, Nian

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Gridley, Thomas

N1 - Funding Information: We thank D. Householder for technical assistance and W. Frankel and T. O’Brien for comments on the manuscript. This work was supported by grants from the NIH (RO1NS36437 and RO1HD34883) to T.G. and by a grant (CA34196) from the National Cancer Institute to The Jackson Laboratory. Research at the Frederick Cancer Research and Development Center was supported by the National Cancer Institute, DHHS, under contract with ABL.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. (C) 2000 Academic Press.

AB - The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. (C) 2000 Academic Press.

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Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases

Abstract

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