Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases

Nian Zhang, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Thomas Gridley

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases. This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c. Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalGenomics
Volume63
Issue number1
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Genetics

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