Abstract
POU domain genes encode a family of highly conserved transacting factors that influence the transcriptional activity of several cell type-specific and ubiquitous genes. We have cloned and sequenced cDNAs encoding a novel mouse POU domain protein, Oct-11, that is closely related within the POU domain to the POU class II proteins, Oct-1 and Oct-2. Recombinant Oc t-11 protein binds specifically to an octamer sequence in vitro. The Oct-11 gene is expressed during mouse embryogenesis and in the adult thymus and testis. In addition, it is abundant in the myeloma cell line P3/NS-1/1-Ag4.1. We describe the structure of Oct-11 and its chromosomal localization, and discuss the evidence that the POU class II gene family has evolved by duplication and divergence of a common ancestral gene.
Original language | English (US) |
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Pages (from-to) | 127-134 |
Number of pages | 8 |
Journal | Nucleic Acids Research |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - Jan 11 1993 |
ASJC Scopus subject areas
- Genetics