Sequences encoding 1,235 bp of the human myosin heavy chain 12 (MYH12) gene have been cloned from a human blain cDNA library by PCR amplification. The human sequence is 95.8% identical to the mouse sequence at the amino acid level, indicating that the MYH12 gene has been evolutionarily well conserved. Somatic cell hyhrid analysis and in situ hybridization place the MYH12 gene on human chromosome 15, at band q21, and extend distally the known region of chromosome 15 linkage homology on mouse chromosome 9.
ASJC Scopus subject areas
- Molecular Biology