Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia

L. Christine Turtzo; M. Douglas Lee; Mingqi Lu; Barbara L. Smith; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Peter Agre

doi:10.1006/geno.1997.4641

Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia

L. Christine Turtzo, M. Douglas Lee, Mingqi Lu, Barbara L. Smith, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Peter Agre

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31 Scopus citations

Abstract

Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

Original language	English (US)
Pages (from-to)	267-270
Number of pages	4
Journal	Genomics
Volume	41
Issue number	2
DOIs	https://doi.org/10.1006/geno.1997.4641
State	Published - Apr 15 1997

ASJC Scopus subject areas

Genetics

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title = "Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia",

abstract = "Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.",

author = "Turtzo, \{L. Christine\} and Lee, \{M. Douglas\} and Mingqi Lu and Smith, \{Barbara L.\} and Copeland, \{Neal G.\} and Gilbert, \{Debra J.\} and Jenkins, \{Nancy A.\} and Peter Agre",

note = "Funding Information: This work was supported in part by National Heart, Lung and Blood Institute Grants HL3391 and HL48268 and by the National Cancer Institute, under contract with ABL. L. C. Turtzo is supported by National Institutes of Health MSTP Grant GM07309.",

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T1 - Cloning and chromosomal localization of mouse aquaporin 4

T2 - Exclusion of a candidate mutant phenotype, ataxia

AU - Turtzo, L. Christine

AU - Lee, M. Douglas

AU - Lu, Mingqi

AU - Smith, Barbara L.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Agre, Peter

N1 - Funding Information: This work was supported in part by National Heart, Lung and Blood Institute Grants HL3391 and HL48268 and by the National Cancer Institute, under contract with ABL. L. C. Turtzo is supported by National Institutes of Health MSTP Grant GM07309.

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AB - Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

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Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia

Abstract

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