Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia

L. Christine Turtzo; M. Douglas Lee; Mingqi Lu; Barbara L. Smith; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Peter Agre

doi:10.1006/geno.1997.4641

Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia

L. Christine Turtzo, M. Douglas Lee, Mingqi Lu, Barbara L. Smith, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Peter Agre

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

Original language	English (US)
Pages (from-to)	267-270
Number of pages	4
Journal	Genomics
Volume	41
Issue number	2
DOIs	https://doi.org/10.1006/geno.1997.4641
State	Published - Apr 15 1997

ASJC Scopus subject areas

Genetics

Access to Document

10.1006/geno.1997.4641

Fingerprint Dive into the research topics of 'Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia'. Together they form a unique fingerprint.

Cite this

@article{a91f14f4b0984ae9b0c06a8b06281383,

title = "Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia",

abstract = "Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.",

author = "Turtzo, {L. Christine} and Lee, {M. Douglas} and Mingqi Lu and Smith, {Barbara L.} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Peter Agre",

year = "1997",

month = apr,

day = "15",

doi = "10.1006/geno.1997.4641",

language = "English (US)",

volume = "41",

pages = "267--270",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - Cloning and chromosomal localization of mouse aquaporin 4

T2 - Exclusion of a candidate mutant phenotype, ataxia

AU - Turtzo, L. Christine

AU - Lee, M. Douglas

AU - Lu, Mingqi

AU - Smith, Barbara L.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Agre, Peter

PY - 1997/4/15

Y1 - 1997/4/15

N2 - Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

AB - Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

UR - http://www.scopus.com/inward/record.url?scp=0031569812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031569812&partnerID=8YFLogxK

U2 - 10.1006/geno.1997.4641

DO - 10.1006/geno.1997.4641

M3 - Article

C2 - 9143504

AN - SCOPUS:0031569812

VL - 41

SP - 267

EP - 270

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -