Cloning and chromosomal localization of mouse aquaporin 4: Exclusion of a candidate mutant phenotype, ataxia

L. Christine Turtzo, M. Douglas Lee, Mingqi Lu, Barbara L. Smith, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Peter Agre

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia phenotype.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalGenomics
Volume41
Issue number2
DOIs
StatePublished - Apr 15 1997

ASJC Scopus subject areas

  • Genetics

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