Clonal diversity and host distribution in Bordetella bronchiseptica

J. M. Musser, D. A. Bemis, H. Ishikawa, R. K. Selander

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

A total of 303 isolates of Bordetella bronchiseptica recovered from 11 host species were characterized by the electrophoretic mobilities of 15 metabolic enzymes, and 21 distinctive multilocus genotypes (electrophoretic types) were distinguished on the basis of allele profiles at the enzyme loci. The population structure of B. bronchiseptica is clonal, and its genetic diversity is limited in comparison with most other pathogenic bacteria, perhaps reflecting a relatively recent origin of the species. Electrophoretic types mark clones which are, in many cases, nonrandomly associated with host species. Clones differing only slightly in overall chromosomal genetic character may have pronounced differences in virulence potential. There was considerable variation among individual clones and clone families in degree of host specificity and among various species of hosts in the diversity of clones causing disease. The diversity of clones infecting dogs was an order of magnitude greater than that of clones infecting pigs. Most bordetellosis in pigs in the United States and Japan was found to be caused by strains of a single multilocus genotype.

Original languageEnglish (US)
Pages (from-to)2793-2803
Number of pages11
JournalJournal of bacteriology
Volume169
Issue number6
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Clonal diversity and host distribution in Bordetella bronchiseptica'. Together they form a unique fingerprint.

Cite this