Clonal analysis of Haemophilus influenzae type b isolates in the United Kingdom

G. Urwin, James M. Musser, Fang Yuan Mei Fang Yuan

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1 Scopus citations


Strains of Haemophilus influenzae type b were collected as pan of an epidemiological study of bacterial meningitis in the North East Thames Region (NETR) of England. Subclones of H. influenzae were identified by outer- membrane protein typing and multilocus enzyme electrophoresis. These were compared with subclones of H. influenzae type b isolated from elsewhere in the UK. The subclone ET 12.5/OMP 3L was identified in 68 % of isolates from cases of meningitis from the NETR. In the isolates from elsewhere in the UK, this subclone was identified in 79 % of sterile-site isolates and 91 % of isolates from non-sterile sites. This subclone predominated in patients of different ages and from different ethnic groups, which suggests that non- Caucasians are infected with the subclone predominating locally. Since ET 12.5/OMP 3L subclone is the most abundant strain isolated in virtually all other Western European countries, these results provide additional evidence that the genetic diversity in the H. influenzae type b population in Europe is relatively restricted.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalJournal of Medical Microbiology
Issue number1
StatePublished - 1995

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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