Clinicopathologic analysis of 124 biopsy-proven peripheral nerve diseases

Seung Mo Hong, Hongil Ha, Jae Hee Suh, Kwang Kuk Kim, Shin Kwang Khang, Jae Y. Ro, Sung Hye Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We reviewed clinical, histological and ultrastructural findings of 124 cases of sural nerve biopsy specimens to delineate the trends of peripheral nerve diseases in our institute. Eighty-one were men and 43 were women. We categorized them into five groups: specific diagnosis (66 cases, 53.2%), axonal degeneration type (47 cases, 37.9%), demyelinating type (4 cases, 3.2%), mixed axonal degeneration-demyelinating type (6 cases, 4.8%) and normal (1 case, 0.9%). Cases with specific diagnosis included 21 inflammatory demyelinating polyneuropathy (15 chronic inflammatory demyelinating polyradiculoneuropathy, 6 Guillain-Barré disease), 13 hereditary motor and sensory neuropathy (7 Charcot-Marie-Tooth type I, 6 Charcot-Marie-Tooth type II), 10 vasculitis, 6 toxic neuropathy, 4 leprosy, 3 diabetic neuropathy, 2 alcoholic neuropathy, 1 Fabry's disease and other specific diseases (5 cases). In our cases, the proportion of specific diagnoses was higher, while the proportion of demyelinating peripheral neuropathies and normal were lower than those of Western series. The results of this study indicate that 1) a close clinicopathologic correlation is important to make a precise diagnosis of peripheral nerve biopsy, 2) Biopsy under strict indication may reduce unnecessary histologic examination, 3) There is no difference in disease pattern of peripheral neuropathy between Western people and Koreans.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalJournal of Korean Medical Science
Issue number2
StatePublished - Apr 2000


  • Biopsy
  • Microscopy, Electron
  • Nerve, Sural
  • Peripheral Nervous System Diseases

ASJC Scopus subject areas

  • Medicine(all)


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