Clinico-pathologic studies in dementia: Nondemented subjects with pathologically confirmed alzheimer's disease

H. Crystal, D. Dickson, P. Fuld, D. Masur, R. Scott, M. Mehler, J. Masdeu, C. Kawas, M. Aronson, L. Wolfson

Research output: Contribution to journalArticlepeer-review

554 Scopus citations


We compared neuropsychological findings in 28 longitudinally evaluated elderly subjects with their postmortem neuropathology, including senile plaque and neurofibrillary tangle counts from standardized sections. Nine of the subjects were not demented when evaluated just prior to their death. Numerous cortical senile plaques and other changes of Alzheimer's disease (AD) occurred in six of nondemented old-old subjects. Five of these six subjects had shown decline on yearly neuropsychological tests but their cognitive impairment was too mild to meet clinical criteria for dementia. Whereas cortical senile plaque count did not distinguish well between demented and nondemented subjects, every subject with numerous cortical neurofibrillary tangles was demented. The nondemented subjects with Alzheimer pathology may have had 'preclinical' AD, or numerous cortical plaques may occur in some elderly subjects who would never develop clinical dementia.

Original languageEnglish (US)
Pages (from-to)1682-1687
Number of pages6
Issue number11
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Clinical Neurology


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