Clinically Significant Enhancement of Voriconazole Efficacy by Moxifloxacin and Gentamicin in Fungal Keratitis

Alice Y. Matoba, Mukul K. Divatia, Robert A. Arguello, Patricia Chévez-Barrios

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

PURPOSE: To report the effect of topical antibiotics moxifloxacin 0.3% and gentamicin 0.3% on the clinical efficacy of topical antifungal agent voriconazole 1% in cases of culture- or biopsy-proven fungal keratitis.

METHODS: Two cases of fungal keratitis in which the addition of topical moxifloxacin or moxifloxacin and gentamicin led to an improved clinical response to topical voriconazole were reviewed retrospectively.

RESULTS: One patient with clinical resistance of his fungal keratitis to both topical voriconazole and natamycin had resolution of his keratitis with the addition of topical moxifloxacin and gentamicin to voriconazole. One patient who had a poor response to topical voriconazole had a dramatic response to the increase of the voriconazole regimen and addition of moxifloxacin.

CONCLUSIONS: In a subset of patients with fungal keratitis, the addition of topical moxifloxacin 0.3% or moxifloxacin 0.3% and gentamicin 0.3% may enhance the therapeutic effect of topical voriconazole 1%.

Original languageEnglish (US)
Pages (from-to)651-654
Number of pages4
JournalCornea
Volume37
Issue number5
DOIs
StatePublished - May 1 2018

ASJC Scopus subject areas

  • Ophthalmology

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