Clinical trials of adult stem cell therapy for peripheral artery disease

Crystal M. Botham, William L. Bennett, John P. Cooke

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Peripheral artery disease (PAD) refers to noncoronary vascular disease affecting the peripheral arteries. Most commonly the term is applied to occlusive arterial disease affecting the limb arteries, typically due to atherosclerosis. Preclinical studies indicate that a variety of stem cell therapies provide growth factors and cytokines for therapeutic angiogenesis. Small clinical trials with bone marrow mononuclear cells, as well as other cell types, have shown promise. However, mechanisms of therapeutic effect, if any, are not understood. Definitive clinical trials are needed to determine if there are any beneficial effects on functional capacity or morbidity.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Issue number4
StatePublished - 2013


  • adult stem cell therapy
  • bone marrow mononuclear cells
  • endothelial progenitor cell
  • peripheral artery disease
  • therapeutic angiogenesis

ASJC Scopus subject areas

  • Medicine(all)


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