Clinical Translation of Extracellular Vesicles

Aayushi Ghodasara, Aun Raza, Joy Wolfram, Carlos Salomon, Amirali Popat

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent attraction as natural materials due to their bioactive surfaces, internal cargo, and role in intercellular communication. EVs contain various biomolecules, including surface and cytoplasmic proteins; and nucleic acids that are often representative of the originating cells. EVs can transfer content to other cells, a process that is thought to be important for several biological processes, including immune responses, oncogenesis, and angiogenesis. An increased understanding of the underlying mechanisms of EV biogenesis, composition, and function has led to an exponential increase in preclinical and clinical assessment of EVs for biomedical applications, such as diagnostics and drug delivery. Bacterium-derived EV vaccines have been in clinical use for decades and a few EV-based diagnostic assays regulated under Clinical Laboratory Improvement Amendments have been approved for use in single laboratories. Though, EV-based products are yet to receive widespread clinical approval from national regulatory agencies such as the United States Food and Drug Administration (USFDA) and European Medicine Agency (EMA), many are in late-stage clinical trials. This perspective sheds light on the unique characteristics of EVs, highlighting current clinical trends, emerging applications, challenges and future perspectives of EVs in clinical use.

Original languageEnglish (US)
Article number2301010
Pages (from-to)e2301010
JournalAdvanced Healthcare Materials
Issue number28
Early online dateJul 8 2023
StatePublished - Nov 2023


  • biomarkers
  • clinical translation
  • clinical trials
  • drug delivery
  • extracellular vesicles (EVs)
  • liposomes
  • Proteins/metabolism
  • Extracellular Vesicles/metabolism
  • Drug Delivery Systems

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science


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