Clinical studies of apoptosis and proliferation in breast cancer

M. Dowsett, C. Archer, L. Assersohn, R. K. Gregory, P. A. Ellis, J. Salter, J. Chang, P. Mainwaring, I. Boeddinghaus, S. R.D. Johnston, T. J. Powles, I. E. Smith

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

The interaction between cell death and cell proliferation determines the growth dynamics of all tissues. Studies are described here which relate the changes in proliferation and apoptosis that occur in human breast cancer during medical therapeutic manoeuvres. Xenograft studies strongly support the involvement of increased apoptosis as well as decreased proliferation after oestrogen withdrawal, and limited studies in clinical samples confirm the involvement of both processes. Cytotoxic chemotherapy induces increases in apoptosis within 24 h of starting treatment. However, after 3 months therapy the residual cell population shows apoptotic and proliferation indices much below pretreatment levels. Further molecular studies of this 'dormant' population are important to characterise the mechanism of their resistance to drug therapy. The early changes in proliferation and apoptosis may provide useful intermediate response indices.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalEndocrine-Related Cancer
Volume6
Issue number1
DOIs
StatePublished - Mar 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

Fingerprint Dive into the research topics of 'Clinical studies of apoptosis and proliferation in breast cancer'. Together they form a unique fingerprint.

Cite this