Clinical phenotype of Brazilian families with spinocerebellar ataxia 10

H. A G Teive, B. B. Roa, S. Raskin, P. Fang, W. O. Arruda, Y. Correa Neto, R. Gao, L. C. Werneck, Tetsuo Ashizawa

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant ataxia caused by an ATTCT repeat expansion in an intron of the SCA10 gene. SCA10 has been reported only in Mexican families, in which the disease showed a combination of cerebellar ataxia and epilepsy. The authors report 28 SCA10 patients from five new Brazilian families. All 28 patients showed cerebellar ataxia without epilepsy, suggesting that the phenotypic expression of the SCA10 mutation differs between Brazilian and Mexican families.

Original languageEnglish (US)
Pages (from-to)1509-1512
Number of pages4
JournalNeurology
Volume63
Issue number8
DOIs
StatePublished - Oct 26 2004

ASJC Scopus subject areas

  • Clinical Neurology

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